Which antibiotic is NOT effective against C. Diff?

C. Diff, or Clostridioides difficile, is a bacterium that causes significant intestinal infections, particularly after antibiotic use. The management of C. Diff infections often includes the use of specific antibiotics that target this pathogen.

Vancomycin and Fidaxomicin are both specifically indicated for the treatment of C. Diff infections. Vancomycin is a glycopeptide antibiotic that is effective against a variety of gram-positive bacteria, including C. Diff when administered orally. Fidaxomicin is a newer antibiotic that exhibits a narrow spectrum of activity specifically targeting C. Diff, making it highly effective in treating and reducing the recurrence of infections caused by this organism. Metronidazole was previously used for treating mild to moderate C. Diff infections and is also active against anaerobic bacteria, including C. Diff; however, its use has become less common with the rise of more effective treatments.

In contrast, Imipenem is a broad-spectrum carbapenem antibiotic that is not typically effective against C. Diff. While Imipenem is effective against a wide range of bacteria, it does not adequately target Clostridioides difficile. Therefore, using Imipenem for C. Diff infections would not provide effective treatment, which is why it is